METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA

US 9,528,109 In force

Overview Sources & methods

Term ends Oct 27, 2028 · Low confidence

Computed 20-year base term

Held by Academisch Ziekenhuis Leiden and Biomarin Technologies B.V.

Filed Nov 14, 2014 as application 14/542,183 · Granted Dec 27, 2016

Base term, 20 years from filing

Today

20 years from filing

Term ends Oct 27, 2028

2008 2028

Clock starts
Oct 27, 2008

Term ends
Oct 27, 2028

Granted
Dec 27, 2016

base term fee events Updated Nov 15, 2026 · includes USPTO assignment & status data published Nov 15, 2026 and grant & fee data published Nov 10, 2026 (weekly) · how we know

None

Term adjustment

No prosecution delay on this record.

No effect

Terminal disclaimer

Resolved from the filed document, referencing US 9,926,557, to Oct 27, 2028. The term already ends on or before that date, so the cap shortened nothing.

2 of 2

Maintenance fees paid

Two maintenance fees can end this term early, the ones due 3.5 and 7.5 years from grant; the third one's grace period runs past the term end. This counts the ones the record shows paid.

How we calculated this date

One row per rule, each showing its own input and what it did to the date. A step we could not verify says so instead of resolving itself.

Step	Input	Date after this step	Confidence
Base term, 20 years from filing	Clock starts Oct 27, 2008, when the earliest non-provisional application in its chain was filed (this one was filed Nov 14, 2014); a parent in its chain could not be resolved (the next row)	Oct 27, 2028	High confidence
Continuity chain	A parent in the chain could not be resolved	dated from this application's own claim	Medium confidence
Patent term adjustment	None on file	no change	High confidence
Terminal disclaimer cap	Disclaimer resolved from the filed document (refs US 9,926,557)	resolves to Oct 27, 2028, no earlier than this term, so no change	High confidence
Patent term extension	None on file	no change	High confidence
Fee events	2 of 2 maintenance fees paid	In force	High confidence
Further caveats on record	The record names parents not resolved: 14200251, 14134971, 14097210, 13094548	Low confidence overall	Low confidence
Computed term end	The steps above, in order	Oct 27, 2028	Low confidence

Sources

Google Patents · The patent document at USPTO · Assignment records at USPTO

USPTO account required: This application in Patent Center · USPTO's maintenance fee lookup

Maintenance fee events come from USPTO's own fee records. Its fee lookup asks for the patent number and the application number.

Not on this page: the patent's family, its recorded assignments and its citation count. USPTO's assignment records, linked above, list every recorded assignment.

Every date shows its work: the base term, any term adjustment or extension, any disclaimer cap, and the maintenance fee record, each with a confidence tier. How this record was built

Computed patent terms end on the dates shown. Related patents and pending applications may cover overlapping subject matter.

In force means the term is running and no lapse is on record. It is not a finding that the patent is valid.

METHODS AND MEANS FOR EFFICIENT SKIPPING OF EXON 45 IN DUCHENNE MUSCULAR DYSTROPHY PRE-mRNA

Term ends Oct 27, 2028 · Low confidence

20-year base term ends Oct 27, 2028

How we calculated this date

Sources